Defective Glucagon Secretion During Hypoglycemia After Intrahepatic But Not Nonhepatic Islet Autotransplantation
نویسندگان
چکیده
منابع مشابه
Intrahepatic glucose flux as a mechanism for defective intrahepatic islet alpha-cell response to hypoglycemia.
OBJECTIVE Glucagon responses to hypoglycemia from islets transplanted in the liver are defective. To determine whether this defect is related to intrahepatic glycogen, islets from inbred Lewis rats were transplanted into the hepatic sinus (H group), peritoneal cavity (P group), omentum (O group), and kidney capsule (K group) of recipient Lewis rats previously rendered diabetic with streptozotoc...
متن کاملIntrahepatic Glucose Flux as a Mechanism for Defective Intrahepatic Islet -Cell Response to Hypoglycemia
OBJECTIVE—Glucagon responses to hypoglycemia from islets transplanted in the liver are defective. To determine whether this defect is related to intrahepatic glycogen, islets from inbred Lewis rats were transplanted into the hepatic sinus (H group), peritoneal cavity (P group), omentum (O group), and kidney capsule (K group) of recipient Lewis rats previously rendered diabetic with streptozotoc...
متن کاملPuzzling About Partial Glucagon Responses to Hypoglycemia in Intrahepatic Islet Recipients: Missing Pieces
Fifteen years ago, Shapiro et al. (1), at the University of Alberta in Edmonton, Canada, published an article in the New England Journal of Medicine that caused great excitement. They reported that seven consecutive recipients with type 1 diabetes who had received intrahepatic infusions of human islet allografts maintained normal levels of HbA1c for more than 1 year after transplant (4.4–14.9 m...
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We examined net pancreatic norepinephrine (NE) spillover, pancreatic polypeptide (PP) release, and the decrement in C-peptide to identify factors involved in the blunted counterregulatory glucagon response in pregnancy. Conscious pregnant [pregnant hypoglycemic (Ph); 3rd trimester; n = 8] and nonpregnant [nonpregnant hypoglycemic (NPh); n = 6] dogs were studied during insulin-induced (approxima...
متن کاملRestoration of Glucose Counterregulation by Islet Transplantation in Long-standing Type 1 Diabetes
Patients with long-standing type 1 diabetes (T1D) may exhibit defective glucose counterregulation and impaired hypoglycemia symptom recognition that substantially increase their risk for experiencing severe hypoglycemia. The purpose of this study was to determine whether intrahepatic islet transplantation improves endogenous glucose production (EGP) in response to hypoglycemia in T1D patients e...
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ژورنال
عنوان ژورنال: American Journal of Transplantation
سال: 2014
ISSN: 1600-6135,1600-6143
DOI: 10.1111/ajt.12776