Defective erythropoiesis in primary myelofibrosis associated with a chromosome 11 abnormality

A fatal congenital defect associated with a unique chromosome abnormality.

Case Report Maternal History. The father and mother were both aged 39 and were first cousins. There was no maternal history of radiation. This was the seventh pregnancy. She had had a previous stillbirth, but all babies with the exception of the present had been born at home. The 5 children, aged from 3 to i6 years, were alive and well. A normal live child was born to the parents I9 months afte...

Defective erythropoiesis in myelodysplastic syndromes.

Primary myelofibrosis associated glomerulopathy: significant improvement after therapy with ruxolitinib

BACKGROUND Primary myelofibrosis (PMF) is a type of myeloproliferative neoplasm (MPN) characterized by the predominant proliferation of megakaryocytes and granulocytes in the bone marrow, leading to the deposition of fibrous tissue, and by a propensity toward extramedullary hematopoiesis. Renal involvement in PMF is rare, but kidney tissue samples from these patients reveal MPN-related glomerul...

Myelofibrosis Associated with Tuberculosis

M YELOFIBROSIS is a disease in which the normal blood-forming elements of the bone marrow are replaced by fibrous tissue with compensatory extramedullary hemopoiesis arising in other organs of the reticulo-endothelial system. Clinically, it is characterized by pains in the long bones, back or abdomen, progressive weakness, pallor and subsequent loss ofweight. The spleen, liver and sometimes the...

Chromosome 7 deletions are associated with unfavorable prognosis in myelofibrosis with myeloid metaplasia.

Chromosome 7 deletions are associated with unfavorable prognosis in myelofibrosis with myeloid metaplasia Several studies suggest a poor prognosis for patients with myelofi-brosis (MF) with an abnormal karyotype, but the prognostic impact of specific cytogenetic lesions is difficult to define. 1 Using conventional cytogenetics, Tefferi et al were able to demonstrate that ϩ8 and 12pϪ were associ...