Dedifferentiation of Mammalian Myotubes Induced by msx1
نویسندگان
چکیده
منابع مشابه
Dedifferentiation of Mammalian Myotubes Induced by msx1
The process of cellular differentiation culminating in terminally differentiated mammalian cells is thought to be irreversible. Here, we present evidence that terminally differentiated murine myotubes can be induced to dedifferentiate. Ectopic expression of msx1 in C2C12 myotubes reduced the nuclear muscle proteins MyoD, myogenin, MRF4, and p21 to undetectable levels in 20%-50% of the myotubes....
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1 Department of neurophysiology, Institute of Basic Medical Sciences, 27 Taiping Road, Beijing 100850, China 2 Institute of Space Medical Engineering, 1 YuanmingYuan West Road, Beijing 100094, China 3 Department of Biochemistry and Molecular Biology, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100083, China 4 Children’s Hospital of Pittsburgh, 5646 Darlington Road, Pittsbu...
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ژورنال
عنوان ژورنال: Cell
سال: 2000
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)00212-9