Decreases in thymopoiesis of astronauts returning from space flight

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Decreases in thymopoiesis of astronauts returning from space flight.

Following the advent of molecular assays that measure T cell receptor excision circles (TRECs) present in recent thymic emigrants, it has been conclusively shown that thymopoiesis persists in most adults, but that functional output decreases with age, influencing the maintenance of a diverse and functional T cell receptor (TCR) repertoire. Space flight has been shown to result in a variety of p...

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ژورنال

عنوان ژورنال: JCI Insight

سال: 2016

ISSN: 2379-3708

DOI: 10.1172/jci.insight.88787