Decreased Polycystin 2 Levels Result in Non-Renal Cardiac Dysfunction with Aging

Decreased Polycystin 2 Levels Result in Non-Renal Cardiac Dysfunction with Aging

Mutations in the gene for polycystin 2 (Pkd2) lead to polycystic kidney disease, however the main cause of mortality in humans is cardiac related. We previously showed that 5 month old Pkd2+/- mice have altered calcium-contractile activity in cardiomyocytes, but have preserved cardiac function. Here, we examined 1 and 9 month old Pkd2+/- mice to determine if decreased amounts of functional poly...

Decreased Levels of Soluble Toll-Like Receptor 2 in Patients with Asthma

Background: Recently, reports have indicated a role for the membrane form of Toll-like Receptor 2 (TLR2) in asthma pathogenesis. In this study we examined soluble TLR2 levels in serum and sputum of asthmatic and healthy subjects. Methods: Serum and sputum samples were obtained from 33 asthmatic and 19 healthy subjects. The asthmatics were classified into four groups according to the Global I...

Polycystin - 1 and Polycystin - 2 Complexes

Characterization of Aging-Associated Cardiac Diastolic Dysfunction

AIMS Diastolic dysfunction is common in geriatric heart failure. A reliable parameter to predict myocardium stiffness and relaxation under similar end-diastolic pressure is being developed. We propose a material and mathematical model for calculating myocardium stiffness based on the concept of linear correlation between [Formula: see text] and wedge pressure. METHODS AND RESULTS We enrolled ...

Polycystin-2 expression is increased following experimental ischaemic renal injury.

BACKGROUND Mutations in PKD2 account for 15% of patients with autosomal dominant polycystic kidney disease. Expression of the PKD2 protein, polycystin-2, is developmentally regulated, suggesting a major role for this protein during nephrogenesis. However, the regulation of polycystin-2 expression in the adult kidney has not been previously explored. METHODS We have utilized an established mod...