Decreased hepatic nitric oxide production contributes to the development of rat sinusoidal obstruction syndrome
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چکیده
منابع مشابه
Hepatic sinusoidal obstruction syndrome following hematopoietic stem cell transplantation.
J.m., a 43-year-old man with acute myelogenous leukemia with a monosomy 7 cytogenetic abnormality, received an allogeneic hematopoietic stem cell transplantation (HscT) from his human leukocyte antigen– matched brother. Past treatments included idarubicin and cytarabine induction therapy followed by a cycle of high-dose cytarabine. J.m. was in complete remission prior to the HscT. The condition...
متن کاملBiomarkers for hepatic sinusoidal obstruction syndrome after hematopoietic cell transplantation
which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Hepatic sinusoidal obstruction syndrome (SOS), previously known as veno-occlusive disease, is one of the major complications during the early period after hematopoietic cell transplantation (HCT). The disease is caused by toxic injury of conditioning therapy...
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Background: According to increased consumption of supplements especially during pregnancy and the teratogenic impact some they on evolution the vital systems of embryos. The purpose of this study to Improve the health of the fetus and prevention of cardiovascular abnormalities as the most common cause of infant mortality. We examined the effects of L-Arginine and L-NAME administration on fetal ...
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Mechanisms leading to the obstruction of the microcirculation in sinusoidal obstruction syndrome (SOS) have been unclear. Because this occurs at the onset of disease, this is a potential key target for therapeutic intervention. Rats were treated with monocrotaline with or without continuous intraportal infusion of glutathione and were studied at 0.5, 1, 2, 4, 6, and 10 days after monocrotaline ...
متن کاملDual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors.
We have recently put forward the hypothesis that the dual inhibition of proinflammatory nitric oxide (NO) and prostaglandins (PG) may contribute to the antiinflammatory properties of nitric oxide synthase (NOS) inhibitors. This hypothesis was tested in the present study. A rapid inflammatory response characterized by edema, high levels of nitrites (NO2-, a breakdown product of NO), PG, and cell...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2003
ISSN: 0270-9139,1527-3350
DOI: 10.1002/hep.1840380416