Decreased expression of four memory genes in non-syndromic cryptorchid males
نویسندگان
چکیده
منابع مشابه
Investigating Seven Recently Identified Genes in 100 Iranian Families with Autosomal Recessive Non-syndromic Hearing Loss
Objectives: Hearing loss (HL) is the most common sensory disorder, and affects 1 in 1000 newborns. About 50% of HL is due to genetics and 70% of them are non-syndromic with a recessive pattern of inheritance. Up to now, more than 50 genes have been detected which are responsible for autosomal recessive non-syndromic hearing loss, (ARNSHL). In Iran, HL is one of the most common disabilitie...
متن کاملEvaluation of Apoptotic Genes Expression and Its Protein after Treatment of Cryptorchid Mice
Introduction: Cryptorchidism has been proved to cause apoptosis in germ cells in respond to changes in the stimulation levels of specific physiological events. The purpose of this study was to determine whether treatment of bilateral cryptorchidism was associated with alterations in testicular gene expression. Methods: To induce bilateral cryptorchid model, immature mice were anesthetized and a...
متن کاملP-209: Decreased Expression of Histone Acetyltransferase CDY1 Gene in Testis Tissue May Lead to Decreased Expression of Transition Protein (TNP) and Protamine (PRM) Genes,Causing Male Infertility
Background: Infertility is a complex medical problem. About 15% of couples are infertile, and male infertility being involved in roughly 50% of the cases. Among these, many cases are associated with a severe impairment of spermatogenesis. During the last stage of spermatogenesis (spermiogenesis), sperm chromatin endures complex modifications in which histones are lost and depositioned with tran...
متن کاملVariations in Multiple Syndromic Deafness Genes Mimic Non-syndromic Hearing Loss
The genetics of both syndromic (SHL) and non-syndromic hearing loss (NSHL) is characterized by a high degree of genetic heterogeneity. We analyzed whole exome sequencing data of 102 unrelated probands with apparently NSHL without a causative variant in known NSHL genes. We detected five causative variants in different SHL genes (SOX10, MITF, PTPN11, CHD7, and KMT2D) in five (4.9%) probands. Cli...
متن کاملGenetics of cleft lip and palate: syndromic genes contribute to the incidence of non-syndromic clefts.
Clefts of the lip and/or palate (CL/P) are among the most common birth defects worldwide. The majority are non-syndromic where CL/P occurs in isolation of other phenotypes. Where one or more additional features are involved, clefts are referred to as syndromic. Collectively CL/P has a major clinical impact requiring surgical, dental, orthodontic, speech, hearing and psychological treatments or ...
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ژورنال
عنوان ژورنال: Endocrine Abstracts
سال: 2013
ISSN: 1479-6848
DOI: 10.1530/endoabs.32.p639