Decision analytic modeling and NSAID gastropathy could we be more sensitive?
نویسندگان
چکیده
منابع مشابه
Current Perspectives in NSAID-Induced Gastropathy
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most highly prescribed drugs in the world. Their analgesic, anti-inflammatory, and antipyretic actions may be beneficial; however, they are associated with severe side effects including gastrointestinal injury and peptic ulceration. Though several approaches for limiting these side effects have been adopted, like the use of COX-2 specific dr...
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متن کاملNSAID Gastropathy: An Update on Prevention
Correspondence to: Kam-Chuen Lai Abstract: Adverse reactions to non-steroidal anti-inflammatory drugs (NSAIDs) are common. Upper gastrointestinal complications including ulcer bleeding, perforation and obstruction are the most serious complications that can result in substantial morbidity and mortality. Many NSAID-using patients present with complications without any preceding symptoms. Risk fa...
متن کاملRole of initial NSAID choice and patient risk factors in the prevention of NSAID gastropathy: a decision analysis.
OBJECTIVE To investigate the role of initial nonsteroidal antiinflammatory drug (NSAID) choice in the prevention of NSAID gastropathy, based on relative clinical and economic effects. METHODS To mimic clinical practice, a symptom-driven decision analytic model was constructed to compare 2 treatment strategies for long-term users of NSAIDs over a 1-year period: Strategy 1-generic NSAID used in...
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OBJECTIVE To determine the effect of misoprostol, a synthetic prostaglandin E1 analogue, on the gastrointestinal tract (GIT) symptoms associated with non-steroidal anti-inflammatory drug (NSAID) administration and on the haemoglobin value, in children. METHODS Retrospective chart review of children attending the paediatric rheumatology clinic at a tertiary referral hospital over a three year ...
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ژورنال
عنوان ژورنال: Journal of General Internal Medicine
سال: 2000
ISSN: 0884-8734,1525-1497
DOI: 10.1046/j.1525-1497.2000.0004009.x