Deciphering regulatory mechanisms for secondary metabolite production in the myxobacterium Sorangium cellulosum So ce56
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چکیده
منابع مشابه
Unusual outer membrane lipid composition of the gram-negative, lipopolysaccharide-lacking myxobacterium Sorangium cellulosum So ce56.
The gram-negative myxobacterium Sorangium cellulosum So ce56 bears the largest bacterial genome published so far, coding for nearly 10,000 genes. Careful analysis of this genome data revealed that part of the genes coding for the very well conserved biosynthesis of lipopolysaccharides (LPS) are missing in this microbe. Biochemical analysis gave no evidence for the presence of LPS in the membran...
متن کاملInsights into the complex biosynthesis of the leupyrrins in Sorangium cellulosum So ce690.
The anti-fungal leupyrrins are secondary metabolites produced by several strains of the myxobacterium Sorangium cellulosum. These intriguing compounds incorporate an atypically substituted γ-butyrolactone ring, as well as pyrrole and oxazolinone functionalities, which are located within an unusual asymmetrical macrodiolide. Previous feeding studies revealed that this novel structure arises from...
متن کاملHeterologous production of the antifungal polyketide antibiotic soraphen A of Sorangium cellulosum So ce26 in Streptomyces lividans.
The antifungal polyketide soraphen A is produced by the myxobacterium Sorangium cellulosum So ce26. The slow growth, swarming motility and general intransigence of the strain for genetic manipulations make industrial strain development, large-scale fermentation and combinatorial biosynthetic manipulation of the soraphen producer very challenging. To provide a better host for soraphen A producti...
متن کاملThe jerangolids: A family of new antifungal compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties of jerangolid A.
An antifungal activity was detected in the culture broth of the myxobacterium, Sorangium cellulosum strain So ce 307. The activity was excreted into the supernatant during the log and early stationary phase. When the organism was fermented in the presence of the adsorber resin XAD-16, the metabolite was quantitatively bound to the resin. The main component, jerangolid A, has structural similari...
متن کاملOrigins of Replication in Sorangium cellulosum and Microcystis aeruginosa
The genome of Sorangium cellulosum has recently been completely sequenced, and it is the largest bacterial genome sequenced so far. In their report, Schneiker et al. (in Complete genome sequence of the myxobacterium Sorangium cellulosum, Nat. Biotechnol., 2007, 25, 1281-1289) concluded that 'In the absence of the GC-skew inversion typically seen at the replication origin of bacterial chromosome...
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2007
ISSN: 0950-382X,1365-2958
DOI: 10.1111/j.1365-2958.2007.05627.x