Deciphering developmental stages of adult myelopoiesis

Deciphering developmental stages of adult myelopoiesis.

The ability to subfractionate minor cellular subsets by multiparameter flow cytometry and to evaluate such cells for functional properties has been used to ascertain lineal relationships and detail developmental hierarchies in the hematopoietic system for more than 20 years. However, steady advances in technology combined with the use of novel cell surface markers continues to redefine the deve...

Adult Behavioral Developmental Stages of Attachment

stage statements In abstract-stage statements, individuals often quantified their emotions following a loss. Although abstract-stage statements were often relatively short, the statements differed from primaryor concrete-stage statements because they contained some kind of recognition that the reaction to an event could have been different or could be variable under different circumstances. (F,...

Deciphering the pathogenesis of tendinopathy: a three-stages process

Our understanding of the pathogenesis of "tendinopathy" is based on fragmented evidences like pieces of a jigsaw puzzle. We propose a "failed healing theory" to knit these fragments together, which can explain previous observations. We also propose that albeit "overuse injury" and other insidious "micro trauma" may well be primary triggers of the process, "tendinopathy" is not an "overuse injur...

ADHD Through Different Developmental Stages

Deciphering the Developmental Dynamics of the Mouse Liver Transcriptome

During development, liver undergoes a rapid transition from a hematopoietic organ to a major organ for drug metabolism and nutrient homeostasis. However, little is known on a transcriptome level of the genes and RNA-splicing variants that are differentially regulated with age, and which up-stream regulators orchestrate age-specific biological functions in liver. We used RNA-Seq to interrogate t...