Deciphering cGMP signatures and cGMP-dependent pathways in plant defence
نویسندگان
چکیده
منابع مشابه
cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action.
To date, studies suggest that biological signaling by nitric oxide (NO) is primarily mediated by cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by cyclic nucleotide phosphodiesterases (PDEs). Effects of cGMP occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. cGMP binding activates PKG, w...
متن کاملInterconvertible cGMP-free and cGMP-bound forms of cGMP-dependent protein kinase in mammalian tissues.
Several vascular and nonvascular mammalian tissue extracts exhibited variable amounts of two peaks (peaks I and II) of cGMP-dependent protein kinase by NaCl elution of DEAE columns. When [3H]cGMP was added to the extracts before chromatography, a peak of protein-bound [3H]cGMP coeluted with peak II. [3H]cGMP was added to purified bovine lung cyclic nucleotide-free enzyme followed by chromatogra...
متن کاملNO inhibits platelet apoptosis by cGMP-dependent and-independent pathways
Background Platelets are specialized anucleate cells that play key roles in hemostasis through their ability to rapidly adhere to subendothelial matrix proteins and endothelial cells (platelet adhesion) and to other activated platelets (platelet aggregation). Platelet activation is an irreversible process resulting ultimately in platelet apoptosis and death. The NO-cGMP-PKG pathway plays an ess...
متن کاملcGMP-dependent signaling pathways in spinal pain processing
Background An exaggerated pain sensitivity is the dominant feature of inflammatory and neuropathic pain both in the clinical setting and in experimental animal models. It manifests as pain in response to normally innocuous stimuli (allodynia), increased response to noxious stimuli (hyperalgesia) or spontaneous pain, and can persist long after the initial injury is resolved. Research over the la...
متن کاملActivation of distinct cAMP-dependent and cGMP-dependent pathways by nitric oxide in cardiac myocytes.
Nitric oxide (NO) donors were recently shown to produce biphasic contractile effects in cardiac tissue, with augmentation at low NO levels and depression at high NO levels. We examined the subcellular mechanisms involved in the opposing effects of NO on cardiac contraction and investigated whether NO modulates contraction exclusively via guanylyl cyclase (GC) activation or whether some contribu...
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ژورنال
عنوان ژورنال: Plant Signaling & Behavior
سال: 2009
ISSN: 1559-2324
DOI: 10.4161/psb.4.4.8066