Dead space drug loss

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Dead space: simplicity to complexity.

CONSIDERABLE UNCERTAINTY existed regarding the magnitude of pulmonary dead space in the immediate post-World War II era. The dead space concept was originated by Bohr (2), who viewed total ventilation as composed of two distinct, but homogeneous, components—alveolar ventilation that participated fully in gas exchange and dead space ventilation in which no respiratory exchange occurred. With kno...

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When physiological dead space (Vd(p)) is calculated for a patient who has alveolar dead space, e.g., after pulmonary vascular occlusion, less than the full volume of attached mechanical dead space (Vd(m)) appears in the measured dead space (Vd(n)). Under these conditions the traditional subtraction of Vd(m) from Vd(n) leads to underestimation of Vd(p) and can give a falsely small ratio of Vd(p)...

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ژورنال

عنوان ژورنال: Anaesthesia

سال: 1994

ISSN: 0003-2409,1365-2044

DOI: 10.1111/j.1365-2044.1994.tb04338.x