Daunorubicin therapy in adult acute lymphatic leukemia
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چکیده
منابع مشابه
Daunorubicin in the therapy of acute granulocytic leukemia.
Institut de Recherches sur les Leucémies,Paris, France ¡M.W., C. J., M. B., Je. B.j; Acute Leukemia Group B Operations Office, Buffalo, New York 14203 [O. J. G., J. F. H./ ; State University of New York-Downstate Affiliated Hospitals, Brooklyn, New York 11238 [R. L./; The National Cancer Institute-Baltimore Cancer Research Center, Baltimore, Maryland, 21211 ¡A.A. S., P. H. W./; The Mount Sin...
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The development of drug resistance by tumor cells is a major obstacle to the cure of human malignancy. Cyclosporin A (CsA) completely reverses primary resistance to vincristine and cross resistance to daunorubicin in a pleiotropic drug-resistant subline of human T cell acute lymphatic leukemia. This subline is over 50-fold resistant to vincristine and fivefold resistant to daunorubicin. CsA has...
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mic enzyme that converts daunorubicm to a principal metabolite, daunorubicino!, in the presence of NADPH. This enzyme, found in mammalian tissues and studied in rat tissue preparations and normal human blood components, is also present in human leukemic myeloblasts. The enzymes from both normal and leukemic leukocytes require NADPH for activity, have similar kinetics and substrate saturation ch...
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Haematologica vol. 85(3):March 2000 7. Dunphy CH, Gregowicz AJ, Rodriguez G Jr. Natural killer cell acute leukemia with myeloid antigen expression. A previously undescribed form of acute leukemia. Am J Clin Pathol 1995; 104:212-5. 8. Nagata T, Higashigawa M, Nagai M, et al. A child case of CD34+, CD33-, HLA-DR-, CD7+, CD56+ stem cell leukemia with thymic involvement. Leuk Res 1996; 20:983-5. 9....
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Remission rates for patients with acute promyelocytic leukemia (APL) have improved with the use of anthracyclines and proper management of disseminated intravascular coagulopathy. In a prospective randomized trial of chemotherapy in patients with acute nonlymphoblastic leukemia, there were 16 patients with APL. All 7 of the patients receiving the amsacrine-containing regimen and 5 of 9 receivin...
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ژورنال
عنوان ژورنال: Cancer
سال: 1972
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(197207)30:1<47::aid-cncr2820300108>3.0.co;2-m