Daughter cell separation is controlled by cytokinetic ring-activated cell wall hydrolysis

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Daughter cell separation is controlled by cytokinetic ring-activated cell wall hydrolysis.

During bacterial cytokinesis, hydrolytic enzymes are used to split wall material shared by adjacent daughter cells to promote their separation. Precise control over these enzymes is critical to prevent breaches in wall integrity that can cause cell lysis. How these potentially lethal hydrolases are regulated has remained unknown. Here, we investigate the regulation of cell wall turnover at the ...

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Fast Mechanically Driven Daughter Cell Separation Is Widespread in Actinobacteria

UNLABELLED Dividing cells of the coccoid Gram-positive bacterium Staphylococcus aureus undergo extremely rapid (millisecond) daughter cell separation (DCS) driven by mechanical crack propagation, a strategy that is very distinct from the gradual, enzymatically driven cell wall remodeling process that has been well described in several rod-shaped model bacteria. To determine if other bacteria, e...

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Formin’ the cytokinetic ring

A ll animal and fungal cells assemble a contractile actomyosin ring to divide themselves in two at the end of mitosis. The rings are constructed from actin fi laments formed de novo at the division site and from fi laments that are assembled elsewhere in the cell and transported to the cleavage zone. Both types of fi lament are generated by actinnucleating formin proteins, but whether one sourc...

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ژورنال

عنوان ژورنال: The EMBO Journal

سال: 2010

ISSN: 0261-4189,1460-2075

DOI: 10.1038/emboj.2010.36