Danger, Metabolism and T Cell Memory

Survival by Inhibiting Peripheral Deletion Synergize to Enhance Memory T Cell Danger and OX40 Receptor Signaling

Memory T Cell Migration

Immunological memory is a key feature of adaptive immunity. It provides the organism with long-lived and robust protection against infection. In organ transplantation, memory T cells pose a significant threat by causing allograft rejection that is generally resistant to immunosuppressive therapy. Therefore, a more thorough understanding of memory T cell biology is needed to improve the survival...

T cell metabolism drives immunity

Lymphocytes must adapt to a wide array of environmental stressors as part of their normal development, during which they undergo a dramatic metabolic remodeling process. Research in this area has yielded surprising findings on the roles of diverse metabolic pathways and metabolites, which have been found to regulate lymphocyte signaling and influence differentiation, function and fate. In this ...

T-Cell Metabolism in Hematopoietic Cell Transplantation

Metabolism, including catabolism and anabolism, is a basic cellular process necessary for cell survival. T lymphocytes have a distinct metabolism that can determine both fate and function. T-cell activation depends on glycolysis to obtain materials and energy for proliferation and effector function. Importantly, T cells utilize different metabolic processes under different conditions and diseas...

Energy Metabolism and T-cell-mediated Cytolysis

The destruction of appropriate target cells by cytolytic thymus-derived lymphocytes (CTL) 1 is an active energy-requiring phenomenon (1-3). In the accompanying paper (4), we presented evidence that T-cell-mediated cytolysis could be supported by either oxidative or glycolytic energy pathways and was in general strongly inhibited only in those situations in which both respiration and glycolysis ...