منابع مشابه
Integrins by Chemoattractants Regulates Neutrophil Migration through Fibrin
Chemoattractants differ in their capacity to stimulate neutrophils to adhere to and to migrate through matrices containing fibrin. Formyl methionyl leucyl phenylalanine (fMLP) stimulates neutrophils to adhere closely to, but not to migrate into, fibrin gels. Leukotriene B4 (LTB4) stimulates neutrophils to adhere loosely to and to migrate through fibrin gels. We report that a 5 b 1 integrins reg...
متن کاملNeutrophil activation and priming during engagement of CD11b/CD18 integrins.
An early first stage of the inflammatory response is neutrophil extravasation, during which neutrophils adhere to endothelial cells lining blood vessels, change shape, and become motile. The neutrophils subsequently migrate through the endothelial layer and chemotax towards the site of inflammation [ I ] . One of the important neutrophil integrins involved in this process is CDI lb/18 (Mac-I) [...
متن کاملNeutrophil Integrins and Matrix Ligands and NET Release
Neutrophils are motile and responsive to tissue injury and infection. As neutrophils emigrate from the bloodstream and migrate toward a site of affliction, they encounter the tissue extracellular matrix (ECM) and thereby engage integrins. Our laboratory studies the neutrophilic response to the fungal pathogen Candida albicans either in the filamentous state of the microbe or to the purified pat...
متن کاملMyeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins.
Recruitment and activation of polymorphonuclear neutrophils (PMNs) reflects a primary immunological response to invading pathogens and has also emerged as a hallmark of vascular inflammation. One of the principal enzymes released upon PMN activation is myeloperoxidase (MPO), a heme protein that not only generates cytotoxic oxidants but also impacts deleteriously on nitric oxide-dependent signal...
متن کاملNeutrophil inhibitory factor abrogates neutrophil adhesion by blockade of CD11a and CD11b beta(2) integrins.
We studied the basis of inhibition of polymorphonuclear leukocyte (PMN) adhesion induced by neutrophil inhibitory factor (NIF), a 41-kDa CD11/CD18 beta(2) integrin-binding protein isolated from the canine hookworm (Ancylostoma caninum). NIF blocked PMN adhesion in a concentration-dependent manner with complete blockade occurring at approximately 10 nM NIF. Because CD11a and CD11b beta(2) integr...
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ژورنال
عنوان ژورنال: Blood
سال: 2016
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2016-06-719849