DACT2 regulates structural and electrical atrial remodeling in atrial fibrillation
نویسندگان
چکیده
منابع مشابه
Structural atrial remodeling alters the substrate and spatiotemporal organization of atrial fibrillation: a comparison in canine models of structural and electrical atrial remodeling.
Several animal models of atrial fibrillation (AF) have been developed that demonstrate either atrial structural remodeling or atrial electrical remodeling, but the characteristics and spatiotemporal organization of the AF between the models have not been compared. Thirty-nine dogs were divided into five groups: rapid atrial pacing (RAP), chronic mitral regurgitation (MR), congestive heart failu...
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BACKGROUND The mechanism(s) for acute changes in electrophysiological properties of the atria during rapid pacing induced atrial fibrillation (AF) is not completely understood. We sought to evaluate the contribution of the intrinsic cardiac autonomic nervous system in acute atrial electrical remodeling and AF induced by 6-hour rapid atrial pacing. METHODS AND RESULTS Continuous rapid pacing (...
متن کاملAlterations in the expression of atrial calpains in electrical and structural remodeling during aging and atrial fibrillation.
The aim of this study was to investigate the correlation between the change in the expression of atrial calpains and electrical, molecular and structural remodeling during aging and atrial fibrillation (AF). Adult and aged canines in sinus rhythm (SR) and with persistent AF (induced by rapid atrial pacing) were investigated. A whole-cell patch clamp was used to measure the L-type Ca2+ current (...
متن کاملIonic mechanisms of electrical remodeling in human atrial fibrillation.
OBJECTIVES Atrial fibrillation (AF) is associated with a decrease in atrial ERP and ERP adaptation to rate as well as changes in atrial conduction velocity. The cellular changes in repolarization and the underlying ionic mechanisms in human AF are only poorly understood. METHODS Action potentials (AP) and ionic currents were studied with the patch clamp technique in single atrial myocytes fro...
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See article by Manios et al. [10] (pages 244 –253) in of AF. Similar observations have been reported by Yu and this issue. co-workers [5]. These authors additionally showed that ERP shortening is a rate-dependent process with shorter Mapping of the atrial electrical activation pattern during cycle length leading to a greater decrease in AERP. human Atrial Fibrillation (AF) has provided evidence...
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ژورنال
عنوان ژورنال: Journal of Thoracic Disease
سال: 2020
ISSN: 2072-1439,2077-6624
DOI: 10.21037/jtd-19-4206