D440N Mutation in the Acid-Labile Subunit of Insulin-Like Growth Factor Complexes Inhibits Secretion and Complex Formation
نویسندگان
چکیده
منابع مشابه
Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain.
We have recently shown that insulin-like growth factor (IGF)-binding protein 5 forms ternary complexes with IGF-I or IGF-II and the acid-labile subunit (ALS) (Twigg, S. M., and Baxter, R. C. (1998) J. Biol. Chem. 273, 6074-6079). Because IGF-binding protein 3 (IGFBP-3) binds to ALS through its basic carboxyl-terminal domain, we tested whether a homologous region present in IGFBP-5 is involved i...
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Age-related osteoporosis is accompanied by an increase in marrow adiposity and a reduction in serum insulin-like growth factor-1 (IGF-1) and the binding proteins that stabilize IGF-1. To determine the relationship between these proteins and bone marrow adiposity, we evaluated the adipogenic potential of marrow-derived mesenchymal stromal cells (MSCs) from mice with decreased serum IGF-1 due to ...
متن کاملCharacterization of insulin-like growth factor-free interaction between insulin-like growth factor binding protein 3 and acid labile subunit expressed from Xenopus oocytes.
The acid-labile subunit (ALS) is known to interact with the IGF binding protein (IGFBP) in the presence of insulin-like growth factors (IGFs). Studies, however, indicate that ALS forms a doublet with IGFBP3, independent of IGFs. To characterize the structural domain required for the IGF-free ALS-IGFBP3 interaction, seven recombinant human IGFBP3 mutants were generated: three deletion mutants an...
متن کاملDeficiency of the circulating insulin-like growth factor system associated with inactivation of the acid-labile subunit gene.
From the Endocrinology Research Center, Division of Endocrinology, Ricardo Gutiérrez Children’s Hospital (H.M.D., A.S.M., M.G.R., P.P., P.S., J.J.H., H.G.J.); and the Division of Pediatrics, J.A. Fernández Hospital (S.V.B.) — both in Buenos Aires, Argentina. Address reprint requests to Mr. Domené at the Endocrinology Research Center (CEDIE), Division of Endocrinology, Ricardo Gutiérrez Children...
متن کاملPlasma levels of acid-labile subunit, free insulin-like growth factor-I, and prostate cancer risk: a prospective study.
BACKGROUND The acid-labile subunit (ALS) acts in the insulin-like growth (IGF) system by binding circulating IGF-I in a ternary complex with binding protein (IGFBP)-3 to prevent IGF-I from crossing the endothelial barrier. Given the role of the IGF system in prostate cancer, ALS may influence carcinogenesis by modulating IGF-I levels or bioavailability. METHODS We undertook a prospective stud...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2011
ISSN: 0888-8809,1944-9917
DOI: 10.1210/me.2010-0295