D2 Receptor Blockade by Flunarizine and Cinnarizine Explains Extrapyramidal Side Effects. A SPECT Study
نویسندگان
چکیده
منابع مشابه
Extrapyramidal side effects with risperidone and haloperidol at comparable D2 receptor occupancy levels.
Risperidone is an antipsychotic drug with high affinity at dopamine D2 and serotonin 5-HT2 receptors. Previous clinical studies have proposed that risperidone's pharmacologic profile may produce improved efficacy for negative psychotic symptoms and decreased propensity for extrapyramidal side effects; features shared by so-called 'atypical' neuroleptics. To determine if routine risperidone trea...
متن کاملParkinsonism, tremor, and depression induced by cinnarizine and flunarizine.
Comment Both these patients were positive for HIV antibody and had a clinical and radiological presentation suggestive of P carinni pneumonia that responded to treatment; thus the criteria fbr a diagnosis of AIDS were satisfied. ' In case 2 the diagnosis was complicated by the previous amiodarone treatment, though pneumonitis induced by amiodarone is unusual at a daily dosage less than 400 mg.2...
متن کاملFlunarizine and cinnarizine-induced parkinsonism: a historical and clinical analysis.
BACKGROUND Drug-Induced Parkinsonism (DIP) represents the second leading cause of Parkinsonism (PK) in several countries. Flunarizine and cinnarizine are some of the most common drugs that cause DIP. This paper reviews the first description of Flunarizine and Cinnarizine-Induced Parkinsonism (FCIP), as well as the subsequent literature, emphasizing epidemiological, clinical and diagnostic aspec...
متن کاملExtrapyramidal side-effects of antipsychotics in a randomised trial.
BACKGROUND There are claims that second-generation antipsychotics produce fewer extrapyramidal side-effects (EPS) compared with first-generation drugs. AIMS To compare the incidence of treatment-emergent EPS between second-generation antipsychotics and perphenazine in people with schizophrenia. METHOD Incidence analyses integrated data from standardised rating scales and documented use of c...
متن کاملExtrapyramidal side-effects and antipsychotics: are second-generation agents
Peluso et al report on the differential effect of first-generation antipsychotics (FGAs) v. second-generation antipsychotics (SGAs) in ameliorating or exacerbating extrapyramidal side-effects (EPS) in a secondary analysis of the CUtLASS-1 trial data. They report their findings as ‘essentially null’ and mention that there is weak evidence for clinically significant differences in emergent or rel...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 1995
ISSN: 0271-678X,1559-7016
DOI: 10.1038/jcbfm.1995.63