منابع مشابه
Role of phospholipid oxidation products in atherosclerosis.
There is increasing clinical evidence that phospholipid oxidation products (Ox-PL) play a role in atherosclerosis. This review focuses on the mechanisms by which Ox-PL interact with endothelial cells, monocyte/macrophages, platelets, smooth muscle cells, and HDL to promote atherogenesis. In the past few years major progress has been made in identifying these mechanisms. It has been recognized t...
متن کاملSpecific Phospholipid Oxidation Products Inhibit Ligand Activation of Toll
Krutzik, Robert L. Modlin, Robert M. Lucas, Junko Nakai, Eric J. Smart, Deven K. Vora and Kimberly A. Walton, Amy L. Cole, Michael Yeh, Ganesamoorthy Subbanagounder, Stephan R. Receptors 4 and 2 Specific Phospholipid Oxidation Products Inhibit Ligand Activation of Toll-Like Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2003 American Heart Association, Inc. All rights reserved. Green...
متن کاملQualitative and quantitative comparison of the cytotoxic and apoptotic potential of phytosterol oxidation products with their corresponding cholesterol oxidation products.
Phytosterols contain an unsaturated ring structure and therefore are susceptible to oxidation under certain conditions. Whilst the cytotoxicity of the analogous cholesterol oxidation products (COP) has been well documented, the biological effects of phytosterol oxidation products (POP) have not yet been fully ascertained. The objective of the present study was to examine the cytotoxicity of bet...
متن کاملSpecific phospholipid oxidation products inhibit ligand activation of toll-like receptors 4 and 2.
OBJECTIVE We have previously shown that phospholipid oxidation products of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (ox-PAPC) inhibit lipopolysaccharide (LPS)-induced E-selectin expression and neutrophil binding in human aortic endothelial cells (HAECs). The current studies identify specific phospholipids that inhibit chemokine induction by Toll-like receptor-4 (TLR4) and -2 (T...
متن کاملSpecific Phospholipid Oxidation Products Inhibit Ligand Activation of Toll-Like Receptors
Objective—We have previously shown that phospholipid oxidation products of 1-palmitoyl-2-arachidonoyl-sn-glycero-3phosphorylcholine (ox-PAPC) inhibit lipopolysaccharide (LPS)-induced E-selectin expression and neutrophil binding in human aortic endothelial cells (HAECs). The current studies identify specific phospholipids that inhibit chemokine induction by Toll-like receptor-4 (TLR4) and -2 (TL...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2007
ISSN: 0021-9258
DOI: 10.1074/jbc.m702865200