Cytotoxic Granule Trafficking and Fusion in Synaptotagmin7-Deficient Cytotoxic T Lymphocytes
نویسندگان
چکیده
منابع مشابه
Cytotoxic T lymphocytes
Cancer stem cells (CSCs)/cancer-initiating cells (CICs) are characterized as a small population of cancer cells that have high tumor-initiating ability. CSCs/CICs are resistant to several cancer therapies, and eradication of CSCs/CICs is essential to cure cancer. How can we eradicate CSCs/CICs? Cytotoxic T lymphocytes (CTLs) might be a promising answer.
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CTLs play a critical role in �ghting chronic virus infection and cancers. Despite the tremendous efforts spent so far, generating potent and highly effective CTLs remain a major roadblock for disease control (prevention and therapies). Activation of CTLs requires different stimuli and is in�uenced by different disease conditions. In this special issue, several papers investigated functions of c...
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Research on CTLs has been booming in recent years—there are more than 250 papers related to CD8 T-cells published everymonth.With such rapid advancement in this particular aspect of immunology alone, it is important to summarize and report information on this hot topic in a timely and organized fashion. Although the submission window for this issue was open for a significantly shorter period co...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2020
ISSN: 1664-3224
DOI: 10.3389/fimmu.2020.01080