منابع مشابه
The effects of Ca2+ buffers on cytosolic Ca2+ signalling
Ca2+ is one of the most important and universal intracellular signalling agents, controlling a multitude of vitally important cellular processes (Petersen & Verkhratsky 2016). The regulating cytosolic Ca2+ signals vary enormously with regard to timing, localization and spatial extent, depending on the specific cell type and the function to be controlled (Petersen & Verkhratsky, 2016). Because o...
متن کاملObservable effects of Ca2+ buffers on local Ca2+ signals.
Calcium signals participate in a large variety of physiological processes. In many instances, they involve calcium entry through inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs), which are usually organized in clusters. Recent high-resolution optical experiments by Smith & Parker have provided new information on Ca(2+) release from clustered IP(3)Rs. In the present paper, we use the mod...
متن کاملMembrane associated Ca2+ buffers in the heart.
Ca2+ is a universal signalling molecule that affects a variety of cellular processes including cardiac development. The majority of intracellular Ca2+ is stored in the endoplasmic and sarcoplasmic reticulum of muscle and non-muscle cells. Calreticulin is a well studied Ca2+-buffering protein in the endoplasmic reticulum, and calreticulin deficiency is embryonic lethal due to impaired cardiac de...
متن کاملMultiple cytosolic calcium buffers in posterior pituitary nerve terminals
Cytosolic Ca(2+) buffers bind to a large fraction of Ca(2+) as it enters a cell, shaping Ca(2+) signals both spatially and temporally. In this way, cytosolic Ca(2+) buffers regulate excitation-secretion coupling and short-term plasticity of release. The posterior pituitary is composed of peptidergic nerve terminals, which release oxytocin and vasopressin in response to Ca(2+) entry. Secretion o...
متن کاملBiphasic Regulation of Mitochondrial Ca2+ Uptake by Cytosolic Ca2+ Concentration
A rise in cytosolic Ca(2+) concentration is used as a key activation signal in virtually all animal cells, where it triggers a range of responses including neurotransmitter release, muscle contraction, and cell growth and proliferation [1]. During intracellular Ca(2+) signaling, mitochondria rapidly take up significant amounts of Ca(2+) from the cytosol, and this stimulates energy production, a...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2010
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a004051