Cytosine derivatized diethylenetriaminepentaacetic acid (dtpa) and Eu(III) complexes for selective recognition of 6-Thioguanine
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چکیده
منابع مشابه
Effect of 6-Thioguanine and Methyl-6-Thioguanine on stability of DNA duplexes
6-Thioguanine (isG) has been used for the past thirty years as an anti-cancer agent in maintenance chemotherapy for childhood acute lymphoblastic leukemia as well as acute myeloid leukemia. Despite its long-standing clinical use, little is understood of the molecular basis of the cytotoxicity associated with 6SG. Research has shown that 6SG is incorporated into DNA during replication after whic...
متن کاملScheduling of arabinosylcytosine and 6-thioguanine therapy.
SUMMARY Mice treated simultaneously with 1-0-D-arabinofuranosyl-cytosine (ara-C) and 6-thioguanine (6-TG) were protected from the lethal effects of 6-TG. No protection was afforded if ara-C was given 16 hr before the 6-TG. DNA synthesis in mouse bone marrow was immediately depressed to 3 to 12% of that of control in various experiments, after treatment with ara-C, 10 to 20 mg/kg; it then reboun...
متن کاملassessment of deep word knowledge in elementary and advanced iranian efl learners: a comparison of selective and productive wat tasks
testing plays a vital role in any language teaching program. it allows teachers and stakeholders, including program administrators, parents, admissions officers and prospective employers to be assured that the learners are progressing according to an accepted standard (douglas, 2010). the problems currently facing language testers have both practical and theoretical implications but the first i...
Circulating immune complexes in rats bearing 6-thioguanine-resistant variants of the 13762 mammary adenocarcinoma.
The relationship between immune complex (IC) formation and tumor cell metastatic potential was investigated in rats inoculated in the footpad with parental 13762 mammary adenocarcinoma cells or 6-thioguanine-resistant (TGR) variant cells. These cell lines are either highly metastatic (13762), nonmetastatic (TGR), or occasionally metastatic ( TGRrev , TGRrevM ). The 13762 TGR rat tumor model thu...
متن کاملMetabolic effects of 6-thioguanine. II. Biosynthesis of nucleic acid purines in vivo and in vitro.
6-Thioguanine (3) has been shown to inhibit a wide spectrum of neoplasms. Its anti-tumor prop erties are markedly potentiated when combined with azaserine, an inhibitor of the synthesis de novo of purines (10, 13). One of these reports also indicated that, for maximum effect, the antimetabolites had to be administered simultaneous ly. These results suggest that thioguanine inter feres with some...
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ژورنال
عنوان ژورنال: Sensors and Actuators B: Chemical
سال: 2017
ISSN: 0925-4005
DOI: 10.1016/j.snb.2017.03.072