Cytoplasmic mRNPs revisited: Singletons and condensates
نویسندگان
چکیده
منابع مشابه
HypothesisEukaryotic mRNPs
Although highly efficient, the clear disadvantage of the prokaryotic operon is the constraint placed upon gene expression by physically coupling the production of multiple proteins in a fixed group. For example, the presence of a nonsense mutation in an operon can result Durham, North Carolina 27710 in polarity effects that disrupt downstream functions. Also, the ability to independently regula...
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Multiple adaptor proteins (e.g., Yra1/Aly/REF1 and SR proteins) drive mRNP • export by loading dimeric export receptor (Mex67-Mtr2/TAP-p15/NXF1-NXT1). In yeast, TREX complex recruited to polymerase; DECD helicase Sub2 loads • Yra1 onto mRNA. In vertebrates, TREX binds cap via splicing-dependent interaction of Aly/REF1(vertebrate Yra1) with CBP80. Export coupled to transcription via SAGA chromat...
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Cytoplasmic RNA granules serve key functions in the control of messenger RNA (mRNA) fate in eukaryotic cells. For instance, in yeast, severe stress induces mRNA relocalization to sites of degradation or storage called processing bodies (P-bodies). In this study, we show that the translation repression associated with glucose starvation causes the key translational mediators of mRNA recognition,...
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ژورنال
عنوان ژورنال: BioEssays
سال: 2020
ISSN: 0265-9247,1521-1878
DOI: 10.1002/bies.202000097