Cytomics-New technologies: Towards a human cytome project
نویسندگان
چکیده
منابع مشابه
Human cytome project, cytomics, and systems biology: the incentive for new horizons in cytometry.
SYSTEMS BIOLOGY Systems biology aims at the quantification of molecular elements and their interrelations in biological systems in response to perturbation to integrate the variety of information into mathematical network models and to correctly predict biological system response to stimuli (1–4). Although promising for single-cell systems such as bacteria, yeast, or cell cultures, difficulties...
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BACKGROUND The elucidation of the molecular pathways from the 20-40.000 genes of the sequenced human genome via investigation of genetic networks and molecular pathways up to the cellular and organismal phenotypes is highly complex and time consuming. STRATEGY AND GOALS The proposed upside-down research strategy of a human cytome project accesses the expressed molecular cell phenotypes by dif...
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A large amount of structural and functional information is obtained by molecular cell phenotype analysis of tissues, organs and organisms at the single cell level by image or flow cytometry in combination with bioinformatic knowledge extraction (cytomics) concerning nuclei acids, proteins and metabolites (cellular genomics, proteomics and metabolomics) as well as cell function parameters like i...
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ژورنال
عنوان ژورنال: Cytometry Part A
سال: 2004
ISSN: 1552-4922
DOI: 10.1002/cyto.a.20047