Cytolytic Virus Activation Therapy for Epstein-Barr Virus–Driven Tumors
نویسندگان
چکیده
منابع مشابه
Cytolytic virus activation therapy for Epstein-Barr virus-driven tumors.
PURPOSE Nasopharyngeal carcinoma (NPC) is causally linked to Epstein-Barr virus (EBV) infection. Because all tumor cells carry EBV, the virus itself is a potential target for therapy. In these tumor cells, EBV hides in a latent state and expresses only a few non-immunogenic proteins for EBV maintenance and contributes to tumor growth. We developed a cytolytic virus activation (CLVA) therapy for...
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The epidemiology of Epstein-Barr virus (EBV) infection in populat ions at dif ferent risk for EBV-associated diseases indicates signif icant differences between the populat ions. EBV infection takes place much earlier in Uganda, where all chi ldren are infected before the age of 2 to 3 years, than in Southeast Asia, where nasopharyngeal carcinoma is prevalent. It is proposed that such early inf...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2012
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-12-0574