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Cytokines in the Germinal Center Niche
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To produce high-affinity antibodies, B cells must undergo iterative cycles of targeted mutagenesis and affinity-based selection. These cycles take place in a structure known as the germinal center, which forms in secondary lymphoid organs upon exposure to antigenic stimuli. Here, we summarize our current understanding of the germinal center reaction.
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ژورنال
عنوان ژورنال: Antibodies
سال: 2016
ISSN: 2073-4468
DOI: 10.3390/antib5010005