Cytokine-secreting follicular T cells shape the antibody repertoire
نویسندگان
چکیده
منابع مشابه
The Effect of Beta Interferon on Dendritic Cells and Cytokine Synthesis by CD4+ T Cells
Background: Dendritic cells (DC) are a key regulator of the immune response, and interferon- beta (IFN-β) is considered an immunomodulatory molecule for DC. Objective: The purpose of this study was to evaluate the ability of IFN-β treated DC to induce cytokine secretion by CD4+ T cells. Methods: Dendritic cells were generated from blood monocytes with granulocyte-monocyte colony-stimulating fac...
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1 Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Pokfulam, Hong Kong, 2 State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, Guangzhou, China, 3 State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guan...
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The development of antibody-based drugs typically begins with the isolation and screening of thousands of antibody-secreting cells, often requiring 4-6 weeks to identify only 1-10 cell lines of interest. We are developing a novel immunobiosensing device to afford direct and rapid assessment of the antibody production of each of thousands of living cells captured on a single slide. Each cell sha...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2009
ISSN: 1529-2908,1529-2916
DOI: 10.1038/ni.1715