Cytokine profile of bronchoalveolar secretion in prolonged course of community acquired pneumonia

Despite existing studies on pathogenetic role of cytokine (CK) system in lung damage pneumonia, there are still controversial issues cytokine-mediated processes that lead to the prolongation inflammatory process tissue this pathology. The article presents study profile bronchoalveolar secretion (BAS) prolonged course community-acquired pneumonia (CAP). To achieve purpose research, patients with CAP first and last 1-2 days hospital stay concentration pro-inflammatory (IL-1β, IL-2, TNFα, IL-6, IL-8) anti-inflammatory CK (IL-4 IL-10) BAS was determined. When studying acute period CAP, it found a disease subsequently had an increase IL-8, TNF-α IL -2), reduction (IL-4, more significant disproportion ratio their opposition pools (IL-1β/IL-10 TNF-α/IL-10) BAS. In conditions generally accepted therapy not course, various rate improvement indicators is defined. progress slower. At time discharge from hospital, most imbalance predominance activity space.