Cytokine profile in seminal fluid of infertile men with concomitant pathologies

The mechanisms of formation male infertility are increasingly becoming immune dependent. This study aims to the role pro-inflammatory and anti-inflammatory cytokines in seminal fluid clarify their spermatogenesis. research is carried out at rheumatology urology departments Danylo Halytsky Lviv National Medical University (Ukraine). 45 infertile men aged 22–48 were examined. They divided into 2 groups: first group – 22 with a systemic autoimmune disease rheumatoid arthritis; second 23 somatically healthy patients idiopathic infertility. control included 27 fertile years. Student's t-test was used compare significant difference mean values between groups. Patients diseases (rheumatoid arthritis) had highest rate leukocytospermia, indicating possible long-term inflammatory process. TGF-β1 level higher infertility, pathology reduced compared group, however these changes not significant. At same time patient both cytokine IL-18 increased approximately by 2.5 times. In pathology, simultaneous increase IFN-γ decrease IL-1β found. ІL-6 plasma groups increased. ratio IL-10/TNF-α decreased arthritis. It found that blood serum controls associated its (r=-0.51, p<0.05). low also concentration this (r=0.62, functioning reproductive systems body closely related interdependent. Disorders reactivity, which accompany development disorders function men. largest number deviations reactivity concomitant diseases. Keywords: cytokines,