CYTOKINE PROFILE IN BLOOD SERUM OF INFERTILE MEN WITH CONCOMITANT PATHOLOGIES

The mechanisms of formation male infertility are increasingly becoming immune-dependent. Immunological isolation the testes is provided by anatomical blood-testis barrier and special tolerance immune system to antigens expressed on gametes. For a better understanding immunopathogenetic infertility, study role various factors required.
 aim: pro-inflammatory anti-inflammatory cytokines in blood serum clarify their spermatogenesis.
 Materials Methods: 45 infertile men aged 22-48 were examined. They divided into 2 groups: first group – 22 with systemic autoimmune disease - rheumatoid arthritis; second 23 somatically healthy patients idiopathic infertility. control included 27 fertile years. Determination concentration was carried out immunoenzymatic method. Student's t-test used compare significant difference mean values between groups. P < 0.05 considered significant.
 Results. Patients diseases (rheumatoid arthritis) had highest rate leukocytospermia, indicating possible long-term inflammatory process. In oligozoospermia diagnosed 3 (13.04%), oligoasthenozoospermia 7 (30.36%), asthenozoospermia 8 (34.78%) leucocytospermia 5 (21.82%). arthritis, IL-18 (cytokine IL-1 family) 1.36 times higher than that men. level IL-6 6 higher, IFN-γ exceeded norm more three times. IL-10 9,4 group. Significant changes cytokine profile recorded increased statistically significantly: 1.45 times, 2.85 2.65 Simultaneously, increased: 3.0 times.
 We also analyzed ratio levels pro- cytokines. increase ІL-10/TNF-α arthritis. Specifically, 3.3 arthritis 4.1 ІL-10/ІFN-γ positive correlations found men: TGF-β1 IFN-γ, TNF-α. group, synthesis TNF-α balanced production IL-10. TGF-β1.
 Conclusions. development associated accompanying pathologies related both local reactivity. decrease IL-1β observed largest number deviations reactivity concomitant diseases.