Cytogenetic characterization of the transgenic Big Blue® Rat2 and Big Blue® mouse embryonic fibroblast cell lines
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چکیده
منابع مشابه
Mutation spectrum of 1,2-dibromo-3-chloropropane, an endocrine disruptor, in the lacI transgenic Big Blue Rat2 fibroblast cell line.
1,2-Dibromo-3-chloropropane (DBCP), a soil fumigant against nematodes, has been extensively studied for genotoxicity, carcinogenicity and damage to male reproduction-related organs, as a possible endocrine disruptor. However, the precise mechanisms involved in DBCP-induced mutagenesis and carcinogenesis are as yet unknown. Thus, in this study the mutagenicity and mutation spectrum of DBCP was d...
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Asbestos-induced mutagenicity in the lung may involve reactive oxygen/nitrogen species (ROS/RNS) released by alveolar macrophages. With the aim of proposing an alternative in vitro mutagenesis test, a coculture system of rat alveolar macrophages (NR8383) and transgenic Big Blue Rat2 embryonic fibroblasts was developed and tested with a crocidolite sample. Crocidolite exposure induced no detecta...
متن کاملDistinction of mutagenic carcinogens from a mutagenic noncarcinogen in the big blue transgenic mouse.
The aromatic amines 2,4-diaminotoluene (2,4-DAT) and 2,6-diaminotoluene (2,6-DAT) are structural isomers that have been extensively studied for their mutagenic and carcinogenic characteristics. Both compounds are rapidly absorbed after oral administration and are equally mutagenic in the Ames test; however, 2,4-DAT is a potent hepatocarcinogen, whereas 2,6-DAT does not produce an increased inci...
متن کاملThe genotoxicity of acrylamide and glycidamide in big blue rats.
Acrylamide (AA), a mutagen and rodent carcinogen, recently has been detected in fried and baked starchy foods, a finding that has prompted renewed interest in its potential for toxicity in humans. In the present study, we exposed Big Blue rats to the equivalent of approximately 5 and 10 mg/kg body weight/day of AA or its epoxide metabolite glycidamide (GA) via the drinking water, an AA treatmen...
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Using Linux for high-performance applications on the compute nodes of IBM Blue Gene/P is challenging because of TLB misses and difficulties with programming the network DMA engine. We present a design and implementation of “big memory”—an alternative, transparent memory space for computational processes, which addresses these difficulties. The big memory uses extremely large memory pages availa...
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ژورنال
عنوان ژورنال: Mutagenesis
سال: 1998
ISSN: 0267-8357,1464-3804
DOI: 10.1093/mutage/13.6.649