منابع مشابه
The synthesis of peptidylfluoromethanes and their properties as inhibitors of serine proteinases and cysteine proteinases.
A synthesis of peptidylfluoromethanes is described that utilizes the conversion of phthaloyl amino acids into their fluoromethane derivatives. These can be deblocked and elongated. The inactivation of chymotrypsin by Cbz-Phe-CH2F (benzyloxycarbonylphenylalanylfluoromethane) was found to be considerably slower than that of the analogous chloromethane. The fluoromethane analogue inactivates chymo...
متن کاملAspartic proteinases and their inhibitors.
Proteolytic enzymes are classified on the basis of their catalytic mechanism as belonging to one of four groups: the serine, cysteine, metallo and aspartic proteinases (Kay, 1982). In contrast to the detailed sequence information and three-dimensional structures that have been produced for many enzymes belonging to the first three groups, relatively little is known about the aspartic proteinase...
متن کاملThe Role of Cysteine Proteinases and their Inhibitors in the Host-Pathogen Cross Talk
Proteinases and their inhibitors play essential functional roles in basic biological processes in both hosts and pathogens. Endo/lysosomal cathepsins participate in immune response in pathogen recognition and elimination. They are essential for both antigen processing and presentation (host adaptive immune response) and activation of endosomal Toll like receptors (innate immune response). Patho...
متن کاملNon-conventional affinity chromatography of serine proteinases and their inhibitors.
From among a wide variety of protein purification techniques affinity chromatography has proved to be particularly effective for separation of proteolytic enzymes and their inhibitors. In this article, following a general description of affinity adsorbents used for purification of proteinases, we overview a simple separation procedure for some serine proteinases and their inhibitors by way of a...
متن کاملHighlight: 29 th Winter School on Proteinases and Their Inhibitors.
The idea of Winter School was born in 1981 out of a collaboration of Vito Turk (Jo ž ef Stefan Institute, Ljubljana, Slovenia) and Hans Fritz (Department of Clinical Chemistry and Clinical Biochemistry at the LudwigMaximilians-University, Munich, Germany) to provide a scientific forum where brand-new, unpublished, and even preliminary results are presented, discussed, and ideas are developed in...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1988
ISSN: 0014-5793
DOI: 10.1016/0014-5793(88)80675-6