Cystatin C, Creatinine, and Albuminuria: Bringing Risk Into 3 Dimensions

Cystatin C versus creatinine in renovascular disease.

Combined association of creatinine, albuminuria, and cystatin C with all-cause mortality and cardiovascular and kidney outcomes.

BACKGROUND Estimated GFR by serum creatinine (eGFRcreatinine) is a pivotal measure of kidney function in clinical practice but can be affected by several non-GFR determinants, resulting in misclassification. Combining multiple kidney markers to predict risk is an area of substantial interest. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS This study followed 9489 adults from visit 4 (1996-1998...

Cystatin C, Albuminuria, and Mortality Among Older Adults With Diabetes

OBJECTIVE Albuminuria and impaired glomerular filtration rate (GFR) are each associated with poor health outcomes among individuals with diabetes. Joint associations of albuminuria and impaired GFR with mortality have not been comprehensively evaluated in this population. RESEARCH DESIGN AND METHODS This is a cohort study among Cardiovascular Health Study participants with diabetes, mean age ...

Creatinine and cystatin C: Shooting at a flying target

I read with great interest the article entitled ‘Significant differences when using creatinine, modification of diet in renal disease, or cystatin C for estimating glomerular filtration rate in ICU patients’ by Lipcsey et al. (1) in the March 2011 issue of the Upsala Journal of Medical Sciences. This article provides an interesting analysis of estimating renal function in critically ill patient...

β2‐Microglobulin, Cystatin C, and Creatinine and Risk of Symptomatic Peripheral Artery Disease

BACKGROUND β2-Microglobulin and cystatin C may have advantages over creatinine in assessing risk associated with kidney function. We therefore investigated whether emerging filtration markers, β2-microglobulin and cystatin C, are prospectively associated with risk of the development of peripheral artery disease (PAD). METHODS AND RESULTS We conducted nested case-control studies among women wi...