Cystathionine Levels in Patients With Huntington Disease

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Increased basal ganglia iron levels in Huntington disease.

OBJECTIVE To quantify in vivo brain ferritin iron levels in patients with Huntington disease (HD) and normal control subjects. DESIGN AND SUBJECTS A magnetic resonance imaging method that can quantify ferritin iron levels with specificity in vivo was employed to study 11 patients with HD and a matched group of 27 normal controls. Three basal ganglia structures (caudate, putamen, and globus pa...

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Milestones in huntington disease.

There have been extraordinary advances in our knowledge of the underlying gene, the protein it encodes, various models of disease, and potential targets for effective therapies for Huntington disease. Huntington disease research has increased exponentially in the past 25 years, and we now understand many of the molecular mechanisms underlying the disease. Still, more work needs to be done befor...

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ژورنال

عنوان ژورنال: PLoS Currents

سال: 2015

ISSN: 2157-3999

DOI: 10.1371/currents.hd.c63b441d04bb6738c0234f91c2b3e312