CYP2C19 genotype and the PPIs - focus on rabeprazole
نویسندگان
چکیده
منابع مشابه
Different contribution of CYP2C19 in the in vitro metabolism of three proton pump inhibitors.
A series of clinical studies on the cytochrome P450 2C19 (CYP2C19) genotype and the pharmacokinetics and pharmacodynamics of three proton pump inhibitors (PPIs), omeprazole, lansoprazole and rabeprazole, have been conducted to establish the individualized pharmacotherapy based on the CYP2C19 genotyping, and in the present study, the CYP2C19 genotype-dependency was more pronounced for omeprazole...
متن کاملAbility of rabeprazole to prevent gastric mucosal damage from clopidogrel and low doses of aspirin depends on CYP2C19 genotype.
BACKGROUND & AIMS Low doses of aspirin can injure the gastric mucosa. It is not clear whether other drugs such as the antiplatelet agent clopidogrel also cause gastric mucosal injury or exacerbate aspirin-induced injury, or whether proton pump inhibitors prevent damage. METHODS Twenty Japanese subjects with different CYP2C19 genotypes were randomly assigned to groups that were given a low dos...
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از گذشته تا کنون، تحقیقات بسیاری صورت گرفته است که همگی به گونه ای بر مثمر ثمر بودن استفاده از استراتژی های یادگیری لغت در یک زبان بیگانه اذعان داشته اند. این تحقیق به بررسی تاثیر دو روش مختلف آموزش واژگان انگلیسی (کلیدی و بافتی) بر تلفظ و دانش لغوی فراگیران ایرانی زیر متوسط زبان انگلیسی و بر ماندگاری آن در حافظه می پردازد. به این منظور، تعداد شصت نفر از زبان آموزان ایرانی هشت تا چهارده ساله با...
15 صفحه اولEffects of CYP2C19 genotype on outcomes of clopidogrel treatment.
BACKGROUND It has been suggested that clopidogrel may be less effective in reducing the rate of cardiovascular events among persons who are carriers of loss-of-function CYP2C19 alleles that are associated with reduced conversion of clopidogrel to its active metabolite. METHODS We genotyped patients from two large, randomized trials that showed that clopidogrel, as compared with placebo, reduc...
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ژورنال
عنوان ژورنال: Journal of Gastroenterology and Hepatology
سال: 2005
ISSN: 0815-9319,1440-1746
DOI: 10.1111/j.1440-1746.2005.04167.x