CYP2A6 slow nicotine metabolism is associated with increased quitting by adolescent smokers

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

CYP2A6 genetic polymorphism and its relation to risk of smoking dependence in male Iranians

Introduction: Nicotine is the psychoactive substance responsible for establishing and maintaining smoking dependence. CYP2A6 is the primary enzyme that inactivates nicotine to cotinine .Genetic variation in CYP2A6 accounts for some of the inter-individual variability in nicotine metabolism and has been indicated to influence smoking behavior and dependence. Therefore, the aim of this study was ...

متن کامل

Adolescent nicotine metabolism: ethnoracial differences among dependent smokers.

Variations in nicotine metabolism are thought to contribute to differences in cigarette consumption between African Americans and Caucasian adult smokers. To investigate the potential mechanism of previously documented lower smoking rates among African-American adolescent smokers seeking cessation treatment, we measured nicotine metabolite ratios as markers of the metabolic disposition of nicot...

متن کامل

CYP2A6 gene polymorphisms impact to nicotine metabolism

Nicotine is a major addictive compound in tobacco cigarette smoke. After being absorbed by the lung nicotine is rapidly metabolized and mainly inactivated to cotinine by hepatic cytochrome P450 2A6 (CYP2A6) enzyme. Genetic polymorphisms in CYP2A6 may play a role in smoking behavior and nicotine dependence. CYP2A6*1A is the wild type of the CYP2A6 gene which is associated with normal or extensiv...

متن کامل

Nicotine dependence among adolescent smokers.

OBJECTIVE To assess nicotine dependence among adolescents to determine whether quitting smoking is associated with the emergence of nicotine withdrawal symptoms and craving, and to identify the factors associated with these symptoms. DESIGN Cross-sectional survey. PARTICIPANTS We studied 2197 10th-grade students in 6 San Jose, Calif, high schools. MAIN OUTCOME MEASURES Smoking status; his...

متن کامل

cyp2a6 genetic polymorphism and its relation to risk of smoking dependence in male iranians

introduction: nicotine is the psychoactive substance responsible for establishing and maintaining smoking dependence. cyp2a6 is the primary enzyme that inactivates nicotine to cotinine .genetic variation in cyp2a6 accounts for some of the inter-individual variability in nicotine metabolism and has been indicated to influence smoking behavior and dependence. therefore, the aim of this study was ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Pharmacogenetics and Genomics

سال: 2013

ISSN: 1744-6872

DOI: 10.1097/fpc.0b013e32835f834d