CYP2A6 slow nicotine metabolism is associated with increased quitting by adolescent smokers
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چکیده
منابع مشابه
CYP2A6 genetic polymorphism and its relation to risk of smoking dependence in male Iranians
Introduction: Nicotine is the psychoactive substance responsible for establishing and maintaining smoking dependence. CYP2A6 is the primary enzyme that inactivates nicotine to cotinine .Genetic variation in CYP2A6 accounts for some of the inter-individual variability in nicotine metabolism and has been indicated to influence smoking behavior and dependence. Therefore, the aim of this study was ...
متن کاملAdolescent nicotine metabolism: ethnoracial differences among dependent smokers.
Variations in nicotine metabolism are thought to contribute to differences in cigarette consumption between African Americans and Caucasian adult smokers. To investigate the potential mechanism of previously documented lower smoking rates among African-American adolescent smokers seeking cessation treatment, we measured nicotine metabolite ratios as markers of the metabolic disposition of nicot...
متن کاملCYP2A6 gene polymorphisms impact to nicotine metabolism
Nicotine is a major addictive compound in tobacco cigarette smoke. After being absorbed by the lung nicotine is rapidly metabolized and mainly inactivated to cotinine by hepatic cytochrome P450 2A6 (CYP2A6) enzyme. Genetic polymorphisms in CYP2A6 may play a role in smoking behavior and nicotine dependence. CYP2A6*1A is the wild type of the CYP2A6 gene which is associated with normal or extensiv...
متن کاملNicotine dependence among adolescent smokers.
OBJECTIVE To assess nicotine dependence among adolescents to determine whether quitting smoking is associated with the emergence of nicotine withdrawal symptoms and craving, and to identify the factors associated with these symptoms. DESIGN Cross-sectional survey. PARTICIPANTS We studied 2197 10th-grade students in 6 San Jose, Calif, high schools. MAIN OUTCOME MEASURES Smoking status; his...
متن کاملcyp2a6 genetic polymorphism and its relation to risk of smoking dependence in male iranians
introduction: nicotine is the psychoactive substance responsible for establishing and maintaining smoking dependence. cyp2a6 is the primary enzyme that inactivates nicotine to cotinine .genetic variation in cyp2a6 accounts for some of the inter-individual variability in nicotine metabolism and has been indicated to influence smoking behavior and dependence. therefore, the aim of this study was ...
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ژورنال
عنوان ژورنال: Pharmacogenetics and Genomics
سال: 2013
ISSN: 1744-6872
DOI: 10.1097/fpc.0b013e32835f834d