CYP2A6 Genotype but not Age Determines Cotinine Half-Life in Infants and Children
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منابع مشابه
CYP2A6 Genotype but not Age Determines Cotinine Half-life in Infants and Children
The formation of cotinine, the main proximate metabolite and a biomarker of nicotine exposure, is mediated primarily by cytochrome P450 (CYP)2A6. Our aim was to determine whether higher cotinine levels in young children exposed to secondhand smoke (SHS) are a result of age-related differences in pharmacokinetics. Forty-nine participants, aged 2-84 months, received oral deuterium-labeled cotinin...
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OBJECTIVE Pharmacokinetic and statistical analyses are reported to elucidate key variables affecting 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) elimination in children and adolescents. DESIGN We used blood concentrations to calculate TCDD elimination half-life. Variables examined by statistical analysis include age, latency from exposure, sex, TCDD concentration and quantity in the body, seve...
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background:childhood zinc deficiency is a common problem in many developing countries where people rely mainly on plant based diets with low zinc contents. zinc supplementation is one of strategies to combat zinc deficiency and its consequences in children. the aim of this community trial was to examine the effect of zinc supplementation on the linear growth of children 6-24 months of age and t...
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ژورنال
عنوان ژورنال: Clinical Pharmacology & Therapeutics
سال: 2013
ISSN: 0009-9236,1532-6535
DOI: 10.1038/clpt.2013.114