منابع مشابه
CYP2A6 genotype, phenotype, and the use of nicotine metabolites as biomarkers during ad libitum smoking.
CYP2A6 inactivates nicotine to cotinine and cotinine to 3-hydroxycotinine. We investigated which of plasma nicotine and metabolites were most related to CYP2A6 genotype and smoking levels. We assessed demographic and smoking histories in 152 Caucasian ad libitum smokers, measured breath carbon monoxide (CO) levels, and determined plasma nicotine, cotinine, and 3-hydroxycotinine by high-performa...
متن کاملSmoking cessation program and CYP2A6 polymorphism.
The relationship between CYP2A6 genotype and smoking status remains unclear although several studies have been reported. In this study, we have investigated the significance of CYP2A6 genotype on smoking habit and treatment of nicotine patch. Sixty-one smokers (1.7%) working in a Japanese company (n = 3585) participated in this smoking cessation program. Forty-four of 61 (72.1%) smokers were tr...
متن کاملVariable CYP2A6-mediated nicotine metabolism alters smoking behavior and risk.
Nicotine is the psychoactive substance responsible for tobacco dependence; smokers adjust their cigarette consumption to maintain brain nicotine levels. In humans, 70 to 80% of nicotine is metabolized to the inactive metabolite cotinine by the enzyme CYP2A6. CYP2A6 can also activate tobacco smoke procarcinogens [e.g., NNK, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone]. In initial studies we f...
متن کاملCYP2A6 genetic polymorphism and its relation to risk of smoking dependence in male Iranians
Introduction: Nicotine is the psychoactive substance responsible for establishing and maintaining smoking dependence. CYP2A6 is the primary enzyme that inactivates nicotine to cotinine .Genetic variation in CYP2A6 accounts for some of the inter-individual variability in nicotine metabolism and has been indicated to influence smoking behavior and dependence. Therefore, the aim of this study was ...
متن کاملSMOKING Association of CYP2A6 deletion polymorphism with smoking habit and development of pulmonary emphysema
Background: Nicotine is responsible for smoking dependence and is mainly metabolised by CYP2A6. Several types of genetic polymorphism of CYP2A6 have been reported, but their relation to smoking habit and chronic obstructive pulmonary disease (COPD) phenotypes has not been fully clarified. Methods: 203 current or ex-smokers (lifelong cigarette consumption (CC) >10 pack years) with subclinical an...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2000
ISSN: 1359-4184,1476-5578
DOI: 10.1038/sj.mp.4000710