CYP2A6 gene polymorphisms impact to nicotine metabolism
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چکیده
منابع مشابه
CYP2A6 gene polymorphisms impact to nicotine metabolism
Nicotine is a major addictive compound in tobacco cigarette smoke. After being absorbed by the lung nicotine is rapidly metabolized and mainly inactivated to cotinine by hepatic cytochrome P450 2A6 (CYP2A6) enzyme. Genetic polymorphisms in CYP2A6 may play a role in smoking behavior and nicotine dependence. CYP2A6*1A is the wild type of the CYP2A6 gene which is associated with normal or extensiv...
متن کاملGenetic polymorphisms in the cytochrome P450 2A6 (CYP2A6) gene: implications for interindividual differences in nicotine metabolism.
During the last couple of years, cytochrome P450 2A6 (CYP2A6; coumarin 7-hydroxylase) has received a lot of attention because it has been shown that it is the principle human nicotine C-oxidase. This enzyme also activates a number of structurally unrelated precarcinogens including many nitrosamines and aflatoxin B1, and metabolizes certain clinically used drugs. There is a pronounced interindiv...
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Each CYP2A6 gene variant metabolizes nicotine differently depending on its enzymatic activities. The normal nicotine metabolizer CYP2A6(*)1A is associated with high scores of nicotine dependence (5-10) on the Fagerström Test for Nicotine Dependence (FTND) scale because it encodes for enzymes that catalyze nicotine 100%. Slow nicotine metabolizers (i.e., CYP2A6(*)1H, CYP2A6(*)4A, CYP2A6(*)9, and...
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Submit Manuscript | http://medcraveonline.com Abbreviations: BGT: Behavioral Genetic Theory; CYP P-450: Cytochrome P450 Enzyme Genes; CO: Carbon Monoxide; FTND: Fagerström Test for Nicotine Dependence; GED: General Education Degree; NRT: Nicotine Replacement Therapy; SNPs: Single Nucleotides Polymorphisms; UW-TTURC: University of Wisconsin Transdisciplinary Tobacco Use Research Center; 3HC/ COT...
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Nicotine is the psychoactive substance responsible for tobacco dependence; smokers adjust their cigarette consumption to maintain brain nicotine levels. In humans, 70 to 80% of nicotine is metabolized to the inactive metabolite cotinine by the enzyme CYP2A6. CYP2A6 can also activate tobacco smoke procarcinogens [e.g., NNK, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone]. In initial studies we f...
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ژورنال
عنوان ژورنال: Medical Journal of Indonesia
سال: 2010
ISSN: 2252-8083,0853-1773
DOI: 10.13181/mji.v19i1.377