Cyclophilin D Modulates Mitochondrial Acetylome

Cyclophilin D modulates mitochondrial acetylome.

RATIONALE Mice lacking cyclophilin D (CypD(-/-)), a mitochondrial chaperone protein, have altered cardiac metabolism. As acetylation has been shown to regulate metabolism, we tested whether changes in protein acetylation might play a role in these metabolic changes in CypD(-/-) hearts. OBJECTIVE Our aim was to test the hypothesis that loss of CypD alters the cardiac mitochondrial acetylome. ...

Cyclophilin D Modulates the Mitochondrial Acetylome

Mitochondrial import of cyclophilin-D.

Mammalian mitochondria contain an inner membrane pore which opens following an increase in matrix calcium. Pore opening has been implicated in tissue damage following ischaemic injury. The pore is reversibly blocked by cyclosporin A [l] suggesting a role for cyclophilin in pore control. A mitochondria1 isoform of cyclophilin (CyP-D) [2,3,4,5] has now been identified. Analysis of the N-terminus ...

Oxidative stress modulates mitochondrial failure and cyclophilin D function in X-linked adrenoleukodystrophy

A common process associated with oxidative stress and severe mitochondrial impairment is the opening of the mitochondrial permeability transition pore, as described in many neurodegenerative diseases. Thus, inhibition of mitochondrial permeability transition pore opening represents a potential target for inhibiting mitochondrial-driven cell death. Among the mitochondrial permeability transition...

Mitochondrial Cyclophilin D in Vascular Oxidative Stress and Hypertension.

Vascular superoxide (O˙2 (-)) and inflammation contribute to hypertension. The mitochondria are an important source of O˙2 (-); however, the regulation of mitochondrial O˙2 (-) and the antihypertensive potential of targeting the mitochondria remain poorly defined. Angiotensin II and inflammatory cytokines, such as interleukin 17A and tumor necrosis factor-α (TNFα) significantly contribute to hy...