Cyclophilin D Acetylation Regulates Cardiac Myocyte Differentiation

Cyclophilin D and acetylation: a new link in cardiac signaling.

CIRCULATION RESEARCH (ISSN 0009-7330) is published semimonthly except one issue per month in November and December and three issues per month in March and August by Lippincott Williams & Wilkins, at 16522 Hunters Green Pkwy, Hagerstown, MD 21740. Business offices are located at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103. Production offices are located at 351 West Camden Str...

Epigenetic regulation of cardiac myocyte differentiation†

Cardiac myocytes (CMs) proliferate robustly during fetal life but withdraw permanently from the cell cycle soon after birth and undergo terminal differentiation. This cell cycle exit is associated with the upregulation of a host of adult cardiac-specific genes. The vast majority of adult CMs (ACMs) do not reenter cell cycle even if subjected to mitogenic stimuli. The basis for this irreversible...

Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function.

RATIONALE Fatty acid oxidation is transcriptionally regulated by peroxisome proliferator-activated receptor (PPAR)α and under normal conditions accounts for 70% of cardiac ATP content. Reduced Ppara expression during sepsis and heart failure leads to reduced fatty acid oxidation and myocardial energy deficiency. Many of the transcriptional regulators of Ppara are unknown. OBJECTIVE To determi...

Foxp1 regulates cardiac outflow tract and endocardial cushion morphogenesis and myocyte proliferation and differentiation

Cyclophilin D regulates necrosis, but not apoptosis, of murine eosinophils.

Eosinophil degranulation and clusters of free extracellular granules are frequently observed in diverse diseases, including atopic dermatitis, nasal polyposis, and eosinophilic esophagitis. Whether these intact granules are released by necrosis or a biochemically mediated cytolysis remains unknown. Recently, a peptidyl-prolyl isomerase located within the mitochondrial matrix, cyclophilin D (PPI...