Cyclooxygenase inhibition and baroreflex sensitivity in humans
نویسندگان
چکیده
منابع مشابه
Cyclooxygenase inhibition and baroreflex sensitivity in humans.
Animal studies suggest that prostanoids (i.e., such as prostacyclin) may sensitize or impair baroreceptor and/or baroreflex responsiveness depending on the site of administration and/or inhibition. We tested the hypothesis that acute inhibition of cyclooxygenase (COX), the rate-limiting enzyme in prostanoid synthesis, impairs baroreflex regulation of cardiac period (R-R interval) and muscle sym...
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Invasive hemodynamic measurements and determination of baroreflex sensitivity were carried out in 12 mildly sodium-depleted normotensive volunteers in a randomized double-blind crossover study with a single dose of converting enzyme inhibitor, MK-421, and placebo. In supine humans at rest, MK-421 caused a reduction in blood pressure through a fall in total peripheral resistance and an increase ...
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The purpose of this study was to evaluate the relationship between the cardiac and sympathetic baroreflex sensitivities within healthy, young humans. The sensitivities of the cardiac and sympathetic baroreflexes were compared in 53 normotensive individuals (28 men and 25 women; age: 24.0 0.9 years; body mass index: 24.0 0.3 cm/kg, mean SEM). Heart rate, arterial blood pressure, and peroneal mus...
متن کاملCardiac baroreflex sensitivity is not correlated to sympathetic baroreflex sensitivity within healthy, young humans.
The purpose of this study was to evaluate the relationship between the cardiac and sympathetic baroreflex sensitivities within healthy, young humans. The sensitivities of the cardiac and sympathetic baroreflexes were compared in 53 normotensive individuals (28 men and 25 women; age: 24.0 ± 0.9 years; body mass index: 24.0 ± 0.3 cm/kg², mean ± SEM). Heart rate, arterial blood pressure, and peron...
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Introduction: Cisplatin (CP) therapy may disturb cardiovascular system control. The objective of this study was to find baroreflex sensitivity (BRS) in CP-induced nephrotoxicity in rats. Materials and Methods: Eighteen male and female Wistar rats were randomly assigned to two groups treated with CP (2.5 mg/kg/day) and the vehicle, for five consecutive days, and then were subjected to surgical ...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2005
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.00357.2004