Cyclin-Dependent Kinase Degradation via E3 Ligase Binding for Potential Disease Modulation in Cancer Treatment
نویسندگان
چکیده
Cyclin-dependent kinases (CDKs) are crucial regulators of cell cycle progression and transcription. Their dysregulation has been implicated in various diseases, including cancer. This Patent Highlight focuses on recent advances the development CDK inhibitor–E3 ligase binding moiety conjugates for targeted degradation their potential applications treating diseases modulated by CDKs. The exemplary PROTAC compounds exhibit a broad range pharmacological activities associated with protein target treatment
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ژورنال
عنوان ژورنال: ACS Medicinal Chemistry Letters
سال: 2023
ISSN: ['1948-5875']
DOI: https://doi.org/10.1021/acsmedchemlett.3c00275