منابع مشابه
Synthesis of inositol glycan cyclic phosphates.
An efficient synthesis of tri-, tetra-, and pentasaccharide cyclic phosphates 1-5, structurally related to natural inositol phosphate glycans, is reported. The title compounds were assembled by PhSeOTf-promoted glycosylation of the known glucosamine precursor, t-butyldimethylsilyl 2-azido-3,6-di-O-benzyl-2-deoxy-beta-D-glucopyranoside (8) with protected 1-methylthio mono-, di-, and trimannoside...
متن کاملBiologic activity of cyclic and caged phosphates: a review.
The recognition in the early 1960s by Morifusa Eto that tri-o-cresyl phosphate (TOCP) is hydroxylated by the cytochrome P450 system to an intermediate that spontaneously cyclizes to a neurotoxic phosphate (saligenin phosphate ester) ignited the interest in this group of compounds. Only the ortho isomer can cyclize and clinically cause Organo Phosphate Induced Delayed Neurotoxicity (OPIDN); the ...
متن کاملBiosynthesis of the formycin family.
The formycin family is composed of the G-ribosides of pyrazolopyrimidine derivatives1'^. In a previous paper we proposed a scheme for their biosynthesis in Nocardia interforma as follows :? ->formycin B monophosphate (FMBP)-» formycin A monophosphate (FMAP) -> formycin A (FMA) -* formycin B (FMB) -> oxoformycin B3). This schemeonly explains the terminal steps of the biosynthetic pathway while t...
متن کاملMetabolism of tubercidin and formycin to their 3':5'-cyclic nucleotides in mammalian cells.
High performance anion exchange chromatography was utilized to demonstrate extensive metabolism of tubercidin and formycin to their corresponding 5’-triphosphates in mouse leukemia EL4 cells and a concomitant decrease in cellular ATP. Efficient anabolism of formycin required the presence of an inhibitor (erythro9-(2-hydroxy-3-nonyl)adenine) of adenosine deaminase in the cellular incubations. Ac...
متن کاملMetabolic conversion of formycin B to formycin A and to oxoformycin B in Nocardia interforma.
A strain of Nocardia interforma having low productivity of formycin A was selected. Washed cells of this strain convert formycin B to oxoformycin B (reaction I), while those of the original strain collected during formycin A producing phase convert formycin B to formycin A (reaction II). Reaction I is inhibited by allopurinol, an inhibitor of xanthine oxidase. Reaction II is inhibited by hadaci...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1978
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.31.456