Cutaneous B-Cell Chronic Lymphocytic Leukaemia resembling a Granulomatous Rosacea

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Cutaneous B-cell chronic lymphocytic leukaemia resembling a granulomatous rosacea.

B-cell chronic lymphocytic leukemia (B-CLL) is a low-grade lymphoproliferative disease. Cutaneous involvement of B-CLL is limited and, in most cases, it represents non-specific manifestations related to an impaired immune system. Leukemic skin infiltrates (leukemia cutis) occur in 4-20% of patients. Herein we report the case of a 65-year-old woman with B-CLL presenting with papular, nodular, an...

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Cutaneous B-cell neoplasms mimicking granulomatous rosacea or rhinophyma.

BACKGROUND Unlike T-cell neoplasms, B-cell lymphoproliferative disorders have a limited clinical spectrum of skin involvement. Cutaneous B-cell neoplasms mimicking rosacea or rhinophyma are rare. OBSERVATIONS We described 12 patients with B-cell lymphoproliferative neoplasms presenting with a facial eruption clinically mimicking rosacea or rhinophyma. Eleven patients were women; ages ranged f...

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T-cell CD38 expression in B-chronic lymphocytic leukaemia.

B-cell chronic lymphocytic leukaemia (B-CLL) is a heterogeneous disease with some patients having an indolent course never needs treatment, while others having rapidly progressive one requires intensive treatment. In recent decades, numerous prognostic markers, such as immunoglobulin variable region heavy-chain (IgVH) mutational status, ZAP-70 and the expression of CD38 on leukaemic cells were ...

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Cutaneous Mycobacterium chelonae infection in chronic lymphocytic leukaemia.

A 67 year old man was diagnosed with chronic lymphocytic leukaemia (CLL) in 1999. He was also known to have hypogammaglobulinaemia and bronchiectasis. He had been previously treated with 12 cycles of chlorambucil, 2 cycles of fludarabine and cyclophosphamide completed in July 2004, and alemtuzumab 30 milligrams subcutaneously three times a week for 12 weeks between January and March 2005. Twelv...

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Stem cell transplantation for chronic lymphocytic leukaemia.

Early results of autologous stem cell transplantation (ASCT) in chronic lymphocytic leukaemia (CLL) suggested a significant proportion of patients remained disease-free for years, raising the possibility of cure. More recent studies have shown no evidence of a plateau in the survival curves indicating that, at best, ASCT may only prolong disease-free survival. Problems remain over progenitor ce...

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ژورنال

عنوان ژورنال: Dermatology Online Journal

سال: 2013

ISSN: 1087-2108

DOI: 10.5070/d31910020033