Current Status of Extended Adjuvant Endocrine Therapy in Early Stage Breast Cancer
نویسندگان
چکیده
منابع مشابه
Current status of adjuvant endocrine therapy for breast cancer.
Adjuvant endocrine therapy is a vitally important modality for treatment of women with resected hormone-sensitive breast cancer as indicated by the presence of estrogen and/or progesterone receptors in the tumor. It is not recommended in those patients whose tumors lack these hormone receptors. Tamoxifen for 5 years has been shown to reduce the risk of recurrence and death irrespective of menop...
متن کاملCurrent Status of Adjuvant Endocrine Therapy for Breast Cancer
Adjuvant endocrine therapy is a vitally important modality for treatment of women with resected hormonesensitive breast cancer as indicated by the presence of estrogen and/or progesterone receptors in the tumor. It is not recommended in those patients whose tumors lack these hormone receptors. Tamoxifen for 5 years has been shown to reduce the risk of recurrence and death irrespective of menopa...
متن کاملScheduling the adjuvant endocrine therapy for early stage breast cancer
Based on the data available through published trial results, we build a mixed integer nonlinear programming (MINLP) model in order to find an optimal treatment plan for a given HR+ early stage breast cancer patient who is postmenopausal. The objective is to maximize the disease-free survival percentage at the end of the treatment period subject to the constraints on the risk of contralateral br...
متن کاملEffectiveness of trastuzumab as adjuvant therapy in patients with early stage breast cancer: A systematic review and meta-analysis
Background: Trastuzumab in combination with chemotherapy has long been established as a standard treatment for HER2-positive patients in early stage breast cancer (BC). The present study aimed at assessing the effectiveness of trastuzumab adjuvant therapy in early stage BC in overall survival (OS) and disease-free survival (DFS). Methods: A systematic review and meta-analysis was ...
متن کاملAdjuvant endocrine therapy for postmenopausal women with early breast cancer.
Results from multiple clinical trials involving aromatase inhibitors have added to the knowledge base relating to endocrine therapy of postmenopausal women with hormone receptor-positive early breast cancer. In the extended adjuvant setting, data from the Austrian Breast and Colorectal Cancer Study Group 6a trial showed an advantage for anastrozole following 5 years of tamoxifen treatment, cons...
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ژورنال
عنوان ژورنال: Current Treatment Options in Oncology
سال: 2018
ISSN: 1527-2729,1534-6277
DOI: 10.1007/s11864-018-0541-1