Current Statistical Approaches to Clinical Pathological Data from Toxicological Studies
نویسندگان
چکیده
منابع مشابه
Statistical approaches to toxicological data.
Statistical techniques as applied to toxicological data are discussed. Issues concerning statistical hypothesis testing and combining studies are considered as well as design of experiments. The problems surrounding risk assessment are also mentioned.
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Organized data management increases the reliability of statistical analysis. The basic purpose of data management is to assure the integrity and the quality of data. To assure data validity, establishing a checking system, such as data audit, would be desirable at the following points: protocol design, supervision of study schedule, definition of data, data collection, choice of tests and proce...
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Cephradine, a semisynthetic cephalosporin antibiotic, has a low order of oral and parenteral toxicity in animals. The oral LD(50) in mice and rats ranged from 5 to >8 g/kg, and the intraperitoneal LD(50) values in mice and rats were 0.7 to 1.5 g/kg and 4.0 g/kg, respectively. The intravenous LD(50) in mice ranged from 3.0 to 3.8 g/kg. In anesthetized dogs, intravenous doses of cephradine (40 an...
متن کاملToxicological approaches to complex mixtures.
This paper reviews the role of toxicological studies in understanding the health effects of environmental exposures to mixtures. The approach taken is to review mixtures that have received the greatest emphasis from toxicology; major mixtures research programs; the toxicologist's view of mixtures and approaches to their study; and the complementary roles of toxicological, clinical, and epidemio...
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ژورنال
عنوان ژورنال: Toxicologic Pathology
سال: 1992
ISSN: 0192-6233,1533-1601
DOI: 10.1177/0192623392020003203