Current State of Precision Medicine in Primary Systemic Vasculitides
نویسندگان
چکیده
منابع مشابه
Mimics of primary systemic vasculitides
The primary systemic vasculitides are well defined entities, but a number of diseases can imitate their clinical, laboratory, radiographic and histological features. The importance of awareness and recognition of these conditions lies in the initiation of correct therapy for the specific disease process and in the avoidance of unnecessary and potentially harmful immunosuppression. In this revie...
متن کاملState of the Art in the Treatment of Systemic Vasculitides
Anti-neutrophil cytoplasm antibodies (ANCA) are associated with small vessel vasculitides (AASV) affecting the lungs and kidneys. Structured clinical assessment using the Birmingham Vasculitis Activity Score and Vasculitis Damage Index should form the basis of a treatment plan and be used to document progress, including relapse. Severe disease with organ or life threatening manifestations needs...
متن کاملClassification of the systemic vasculitides
Systemic vasculitis, an inflammatory necrotizing disease of the blood vessel walls, can occur secondary to autoimmune diseases, including connective tissue diseases. Various pathogenic mechanisms have been implicated in the induction of vasculitis, including cell-mediated inflammation, immune complex-mediated inflammation and autoantibody-mediated inflammation. This inflammatory activity is bel...
متن کاملIntravenous Immunoglobulin Therapy in Primary Vasculitides
Vasculitis is defined as chronic blood vessel inflammation confirmed by histologic evidence. The typical course of the disease may lead to blood vessel stenosis/occlusion causing organ ischemia, or to thinning of the blood vessel which results in aneurysm formation or hemorrhage. Although in 1994 the American College of Rheumatology introduced morphological and histopathological classification ...
متن کاملVirus-induced Systemic Vasculitides: New Therapeutic Approaches
The best therapeutic strategy in virus-induced vasculitides should take into account the etiology of the disease and be adapted to the pathogenesis. The combination of antiviral treatments and plasma exchanges has been proven effective in polyarteritis nodosa (PAN). In human immunodeficiency virus (HIV)-related vasculitis this strategy is also effective and does not jeopardize, like cytotoxic a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2019
ISSN: 1664-3224
DOI: 10.3389/fimmu.2019.02813