Curcuminoids from the Vietnamese Curcuma longa: Phytochemical analysis and biological activities

نویسندگان

چکیده

A phytochemical investigation on the ethanolic (EtOH) extract of Vietnamese Curcuma longa (C. longa) rhizomes has led to isolation four curcuminoids including curcumin (1), demethoxycurcumin (2), bisdemethoxycurcumin (3), and cyclocurcumin (4). The chemical structure compounds 1-4 was elucidated by Nuclear magnetic resonance (NMR) Mass spectrometry (MS) spectral data. Based High-performance liquid chromatography (HPLC) quantitative analysis, amounts three major 1-3 in C. were calculated reached 7.215±0.101, 3.927±0.031, 2.255±0.049 mg/g, respectively. Curcuminoids have induced IC50 values 9.23-14.6 μg/ml a 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay as compared with that positive control resveratrol (IC50 11.5 μg/ml). Compounds ranging between 8.7-15.54 better than acarbose 169.14 μg/ml) α-glucosidase inhibitory examination. In addition, EtOH also responsible for inhibitions against enzyme acetylcholinesterase cancer cell lines epidermoid carcinoma (KB), hepatocellular (HepG2), lung (SK-LU-1), breast (MCF7).

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ژورنال

عنوان ژورنال: Vietnam Journal of Science, Technology and Engineering

سال: 2022

ISSN: ['2525-2461', '2615-9937']

DOI: https://doi.org/10.31276/vjste.64(3).19-23